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Site of action of nitrofurantoin in experimental urinary tract infection.

Applied Microbiology, 01 Oct 1969, 18(4):547-549
https://doi.org/10.1128/am.18.4.547-549.1969 PMID: 4905033 PMCID: PMC378032

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Abstract 

The effectiveness of nitrofurantoin in suppressing bacterial growth in the urinary tract was evaluated by using two different experimental models. Pyelonephritis was produced in rats by direct inoculation of 10(4)Escherichia coli in the medulla of left kidney. Ascending urinary tract infection was induced by inoculation into the urinary bladder of 10(7)Proteus mirabilis, after a partial cystectomy. Nitrofurantoin was shown to be effective in suppressing bladder bacteriuria, in preventing ascending pyelonephritis, and also in preventing bacterial multiplication in kidney tissue following direct inoculation.

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Appl Microbiol. 1969 Oct; 18(4): 547–549.
PMCID: PMC378032
PMID: 4905033

Site of Action of Nitrofurantoin in Experimental Urinary Tract Infection

Heonir Rocha, Edson Da Silva Teles, and Milton Barros
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Abstract

The effectiveness of nitrofurantoin in suppressing bacterial growth in the urinary tract was evaluated by using two different experimental models. Pyelonephritis was produced in rats by direct inoculation of 104Escherichia coli in the medulla of left kidney. Ascending urinary tract infection was induced by inoculation into the urinary bladder of 107Proteus mirabilis, after a partial cystectomy. Nitrofurantoin was shown to be effective in suppressing bladder bacteriuria, in preventing ascending pyelonephritis, and also in preventing bacterial multiplication in kidney tissue following direct inoculation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BUZARD JA, BENDER RC, NOHLE EG, HUMPHREY DT, PAUL MF. Renal tubular transport of nitrofurantoin. Am J Physiol. 1962 Jun;202:1136–1140. [Abstract] [Google Scholar]
  • Currie GA, Little PJ, McDonald SJ. The localisation of cephaloridine and nitrofurantoin in the kidney. Nephron. 1966;3(5):282–288. [Abstract] [Google Scholar]
  • KATZ YJ, COCKETT AT, MOORE RS. RENAL LYMPH AND ANTIBACTERIAL LEVELS IN THE TREATMENT OF PYELONEPHRITIS. Life Sci. 1964 Nov;3:1249–1262. [Abstract] [Google Scholar]
  • Rocha H, Barros M. Experimental pyelonephritis: characteristics of infection in rats following reduction of bladder capacity. Proc Soc Exp Biol Med. 1965 Oct;120(1):122–124. [Abstract] [Google Scholar]
  • WOODRUFF MW, MALVIN RL, THOMPSON IM. The renal transport of nitrofurantoin. Effect of acid-base balance upon its excretion. JAMA. 1961 Apr 1;175:1132–1135. [Abstract] [Google Scholar]
Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

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