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Oct 6, 2021 · The median overall survival was nearly 64 months in patients treated with both drugs and over 51 months in those who only received letrozole.
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Breast Cancer. Early breast cancer. Indicated in combination with an aromatase inhibitor for the adjuvant treatment of hormone receptor (HR)-positive, ...
Ribociclib
Medication
Ribociclib, sold under the brand name Kisqali, is a medication used for the treatment of certain kinds of breast cancer. Ribociclib is a kinase inhibitor. It was developed by Novartis and Astex Pharmaceuticals. Wikipedia
AHFS/Drugs.com: Monograph
ATC code: L01EF02 (WHO)
Elimination half-life: 32.0 (29.7–54.7) hrs
Metabolism: Liver (CYP3A4)
Other names: LEE 011
Protein binding: ~70%
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Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial.
HIGHLIGHTS OF PRESCRIBING INFORMATION. These highlights do not include all the information needed to use. KISQALI safely and effectively.
The MONALEESA-7 trial compared ribociclib plus endocrine therapy (ET) with placebo as first-line treatment of advanced luminal/HER2-negative breast cancer (ABC) ...
Kisqali can be taken with or without food (see section 4.5). Patients should be encouraged to take their dose at approximately the same time each day, ...
Dec 1, 2018 · Ribociclib is an orally administered, selective, reversible small molecule inhibitor of cyclin-dependent kinases (CDK).
May 8, 2018 · Ribociclib is a unique cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of ...
Apr 9, 2024 · We currently expect regulatory review of ribociclib in eBC to proceed as planned.
Indications: Hormone receptor (HR) positive, HER-2 negative advanced or metastatic breast cancer in combination with a non-steroidal aromatase inhibitor or ...
