How to Kill Albert Wesker in Resident Evil 5

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Last Updated: July 2, 2020

Wesker may seem intimidating and pretty tough to defeat (especially on higher difficulty settings), but following these simple tips should help you survive and prosper.

Method 1

Method 1 of 4:

Preparing for the fight

First, you must have proper equipment to succeed in defeating him for all three encounters. The recommendations are listed below.

1
What weapon's the best? Magnums and shotguns over sub-machine guns and pistols is the way to go.
- For Wesker, a rocket launcher is the best (and expensive) way to end fights.
- For knocking out Jill, a grenade launcher with flash grenades is the best option.
You should have at least 3 first aid/herbs for each partner.

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Method 2

Method 2 of 4:

First encounter

1
You must flee the area. As of right now, Wesker has the advantage of Jill providing gun fire for him. To negate this effect, run to the right side of your starting position and head for the blue door.
- Stay behind the column by the door to avoid Jill's gunshots.
- If playing co-op, one partner should shoot Wesker to draw attention away.
- The partner in cover should shoot Jill with the flash rounds in the grenade launcher.
2
A cutscene should play. When it ends, Chris should turn around and head up the stairs and into a hallway.
- As Chris, take cover at the end of the hallway and wait until Wesker comes. Then, shoot him quickly as many times as possible.
- As Sheva, wait for the above situation to unfold by hiding behind a column. Then when Chris starts shooting Wesker, head up into the hallway he's in and then shoot Wesker from behind while he fights Chris.
3
At this point, he either dashes toward you or he's dazed.
- If he dashes then run away and repeat step 2.
- If he is stunned then run up to him and complete the quick time event.
Shooting him while he holds the rocket instantly ends the fight. Make sure he fights the person not holding the rocket launcher so it's easier that way.

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Method 3

Method 3 of 4:

2nd encounter

Then, turn them off. They're in the corner of the map.
A cutscene should play.
Shoot the rocket and the fight is over.

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Method 4

Method 4 of 4:

3rd encounter

1
At the start, turn around and run towards the bridge. A cutscene should play. After that, your roles will be different.
- As Chris, get to the center of the map and get Wesker to start trying to hit you.
- As Sheva, while Wesker tries to hit Chris, pull out a rocket launcher and shoot his orange spot on the back. Fight over.

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Tips

Bring a shotgun and magnum. Use the shotgun for close range and tight hallways and the magnum for mid-long range. Try to upgrade the firepower for both weapons.

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If playing online Co-op, have one person distract Wesker while the other shoots him.

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Grab Jill by the back and have your partner tear the spider off.

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Warnings

Never fight Jill and Wesker at the same time.

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Jill has a SMG that can lower your health greatly.

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Wesker can take more damage than you can. Hide if necessary.

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For the 2nd encounter, watch out for Wesker trying to jab you with his hand. You can dodge by QTE or else if you fail, he will instantly kill you.

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Don't go near Wesker. He is an expert at fighting.

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Watch out for Wesker shooting his magnum. You can dodge the attack by a QTE or moving in circles.

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Never fight one on one with Wesker.

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